What is Melanotan 2 ?
Melanotan 2 Tanning Injections (mod ieħor magħruf as MT2) was first synthesized at the University of Arizona. Researches there knew li onc of the best defenses against skin cancer was melanin actated in the skin, a tan. They hypothesized that an effective way to reduce skin cancer rates in people be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure. The body's naturally occuring hormone MSH causes melanogenesis, a process by li the skin's pigment cells (melanocytes) produce the skin's pigment (melanin). They tested to see if admanjing this endogenous hormone to the body directly could be an effective method to cause sunless tanning. What they found was that filwaqt li deher to work, natural MSH had too short a half life in the body to be practical as a a terapewtika droga. Allura huma deċiżi biex isibu a aktar qawwi u stabbli alternattiva, wieħed li ikun aktar prattiku.
After synthesizing and screening hundreds of molecules, the researchers headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7] MSH, that was approimately 1,000 times more potent than the natural MSH. They dubbed this new peptide molecule, "Melanotan" (later Melanotan-1, now know as afamelanotide). They subsequently developed another analog, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2), which they called "Melanotan" Tanning Injections. The scientists hoped to use these peptides to combat melanoma by stimulating the body's natural pigmentary mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn, they hypothesized, could reduce the potential for skin damage that can eventually lead to skin cancer.
A pilota phase I clinical trial conducted on three males by the College of Medacine, Pharmacology Department, University of Arizona in Tuscon, Arizona pulished in 1996 reported that, "Melanotan" Tanning Injections has tanning activity in humans given only 5 low doses every other day by subcutaneous injection." The side effects reported were mild nausea and a "stretching and yawning complex" that correlated with spontaneous pene erezzjonijiet.
The Department of Pharmacology, University of Arizona College of Medacin published in 1998 that involved 10 men who suffered from psychogenic erectile dysfunction. Their trial concluded that, "Melanotan" Tanning Injections is a potent initiator of erections in men with pyschogenic erectile dydfunction and has manageable side effects at a dose of 0.025mg/kg.
A clinical study published in 2000 of 20 men with psychogenic and organic erectile dysfunction conducted at the Section of Urology of The University of Arizona College of Medacin concluded, "that Melanotan II Tanning Injections is a potent initiator of penile erection in men with ecrectile dysfunction.
Deskrizzjoni
MT-2 (or Melanotan II) is ieħor sintetiku peptide of ormoni natura u lactam ċikliku analogu of melanocortin proteina ormon alpha-melanocyte stimulazzjoni ormon; Its molecular weight/mass is 1024.2 with molecular formula is C50H69N15O9. This analog has typical features of proteins. Melanotan II was purposely created in 1991 by American researchers from Arizona under leadership of Hruby/Hedley, filwaqt li huma kienu qed ifittxu għal aktar stabbli u potenti modifika ta' primal MSH. After li numerous clinical studies take part in different countries to identifika efficacy of newly developed peptide.
Like its predecessor, Melanotan I, MT-2 plays role in stimulating melanogenesis and by that provi provi protective mechanism against UV rays since under its actions melanocytes are able to increase production and secretion of hormone melanin li is kind of peptides. Madankollu, xjenzati kienu wkoll kapaċi biex avviż karatteristika ta' dan riċerka kompost li huwa ċerti aphrodisiac effetti. It ukoll għandu ħafif pożittiv il-mobilizzazzjoni tax-xaħam l-effett.
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